Recombinant Human Signal-Regulatory Protein a-1/SIRPA/CD172a (C-Fc)
Product Sizes
10 µg
£549.00
32-8826-10UG
50 µg
£706.00
32-8826-50UG
About this Product
- SKU:
- 32-8826
- Extra Details:
- Source: Human cells. MW :64.1kD. Recombinant Human Signal-Regulatory Protein alpha 1 is produced by our Mammalian expression system and the target gene encoding Glu31-Arg370 is expressed with a Fc tag at the C-terminus. Signal Regulatory Protein a (SIRPa) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPa contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPa can express in various tissues; mainly on brain and myeloid cells; including macrophages; neutrophils; dendritic and Langerhans cells. It also can detect in neurons; smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPa acts as docking protein and induces translocation of PTPN6; PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPa shows adhesion of cerebellar neurons; neurite outgrowth and glial cell attachment. SIRPa engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis; mast cell activation and dendritic cell activation
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
