Recombinant Mouse Activin Receptor-like Kinase 1/ALK-1/ACVRL1 (C-Fc)
Product Sizes
10 µg
£433.00
32-8639-10UG
50 µg
£493.00
32-8639-50UG
About this Product
- SKU:
- 32-8639
- Extra Details:
- Source: Human Cells. MW :38.1kD. Recombinant Mouse Activin Receptor-like Kinase 1 is produced by our Mammalian expression system and the target gene encoding Asp23-Pro119 is expressed with a Fc tag at the C-terminus. Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF- beta superfamily of ligands; which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis; wound healing; and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains; a glycine and serine rich region preceding the kinase-domain; and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1 is mainly expressed in endothelial cells regulating proliferation and migration in vitro and angiogenesis in vivo. Mutations in ALK-1 as well as in endoglin are associated with hereditary hemorrhagic telangiectasia (HHT); suggesting ALK-1 plays a critical role for in the control of blood vessel development or repair.
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
