Recombinant Human RANK L/TRANCE/TNFSF11 (N-6His)
Product Sizes
10 µg
£554.00
32-8631-10UG
50 µg
£847.00
32-8631-50UG
About this Product
- SKU:
- 32-8631
- Extra Details:
- Source: E.coli. MW :22.4kD. Recombinant Human Receptor Activator of NF-kappa-B ligand is produced by our E.coli expression system and the target gene encoding Ile140-Asp317 is expressed with a 6His tag at the N-terminus. CD254; also known as RANKL; TNFSF11; TRANCE; OPGL and ODF; is a type II membrane protein of the tumor necrosis factor (TNF) superfamily; and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-kB (RANK). When RANKL binds to RANK; it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades; including the NFkB; mitogen-activated protein kinases (MAPK); activating protein 1 (AP-1); and nuclear factor of activated T cells (NFATc1); resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle; thymus; liver; colon; small intestine; adrenal gland; osteoblast; mammary gland epithelial cells; prostate and pancreas.
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
