Recombinant Mouse Lymphocyte Activation Gene 3/LAG-3/CD223 (C-6His)
Product Sizes
10 µg
£554.00
32-8624-10UG
50 µg
£847.00
32-8624-50UG
About this Product
- SKU:
- 32-8624
- Extra Details:
- Source: Human Cells. MW :46.2kD. Recombinant Mouse LAG-3 is produced by our Mammalian expression system and the target gene encoding Ser23-Leu442 is expressed with a 6His tag at the C-terminus. Lymphocyte-activation gene 3 (LAG3); also known as CD223; is a type I transmembrane protein with four extracellular Ig-like domains; designated D1 to D4 and belongs to the immunoglobulin superfamily. The gene for LAG3 lies adjacent to the gene for CD4 on human chromosome 12p13.32 and shares approximately 20% identical to the CD4 gene. LAG3 is expressed on activated T cells; natural killer cells; B cells and plasmacytoid dendritic cells. LAG3 binds with high affinity to MHC class II molecules; and it interferes competitively with the binding of CD4 to MHC class II and thereby blocks the transduction of stimulatory signals mediated by this interaction. LAG3 negatively regulates cellular proliferation; activation; and homeostasis of T cells; and plays an important role in Treg suppressive function. LAG3 is the target of various drug development programs to develop new treatments for cancer and autoimmune disorders. The soluble form; sLAG-3; is being developed as a cancer drug.
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
