Recombinant Human Thymidine Kinase; Cytosolic/TK1 (C-6His)
Product Sizes
10 µg
£604.00
32-8444-10UG
50 µg
£897.00
32-8444-50UG
About this Product
- SKU:
- 32-8444
- Extra Details:
- Source: Human Cells. MW :26.5kD. Recombinant Human Thymidine kinase 1 is produced by our Mammalian expression system and the target gene encoding Met1-Asn234 is expressed with a 6His tag at the C-terminus. Thymidine kinase 1(TK1) belongs to the thymidine kinase family. It is located in the cytoplasm; and phosphorylated on Ser-13 in mitosis during post-translational modification. Two forms of this protein have been identified in animal cells; one in cytosol TK1 and one in mitochondria TK2. Thymidine kinases have a key function in the synthesis of DNA and thereby in cell division; as they are part of the unique reaction chain to introduce deoxythymidine into the DNA. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; while it is very low in resting cells. TK1 acts as a homotetramer; and can transform thymidime to thymidine 5'-phosphate with the help of ATP
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Store at -20[o]C; stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
