Recombinant Human Lymphocyte Cytosolic Protein 2/LCP2 (C-6His; N-T7 tag)
Product Sizes
10 µg
£604.00
32-8354-10UG
50 µg
£897.00
32-8354-50UG
About this Product
- SKU:
- 32-8354
- Extra Details:
- Source: E. coli. MW :62.6kD. Recombinant Human SLP-76 is produced by our E.coli expression system and the target gene encoding Met1-Pro533 is expressed with a T7 tag at the N-terminus; 6His tag at the C-terminus. Lymphocyte cytosolic protein 2(LCP2)contains a SAM domain and a SH2 domain. It is highly expressed in spleen; thymus and peripheral blood leukocytes; T-cell and monocytic cell lines; but expressed at lower level in B-cell lines. LCP2 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. It is phosphorylated after T-cell receptor activation by ZAP70; ITK and TXK; which leads to the up-regulation of Th1 preferred cytokine IL-2 during post-translational modification. Studies using LCP2-deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Store at -20[o]C; stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
