Recombinant Human Caspase-10/CASP10 (C-6His)
Product Sizes
10 µg
£604.00
32-8198-10UG
50 µg
£897.00
32-8198-50UG
About this Product
- SKU:
- 32-8198
- Extra Details:
- Source: E. coli. MW :30.1kD. Recombinant Human Caspase-10 is produced by our E.coli expression system and the target gene encoding Val220-Ile480 is expressed with a 6His tag at the C-terminus. Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granzyme B and autocatalytic activity generate the two active subunits: Caspase-10 subunit p23/17; Caspase-10 subunit p12. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the execution-phase of cell apoptosis; the initiation and execution. Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1; -4; -5; and -13); apoptosis initiation (caspase-2; -8; -9; -and -10); and apoptosis execution (caspase-3; -6; and -7). CASP10 cleaves and activates caspases 3 and 7; but itself is processed by caspase 8. Defects in CASP10 are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Store at -20[o]C; stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
