Recombinant Mouse Collagen Alpha-1(XVIII) Chain/Endostatin (C-6His)
Product Sizes
10 µg
£493.00
32-7865-10UG
50 µg
£656.00
32-7865-50UG
About this Product
- SKU:
- 32-7865
- Extra Details:
- Source: Human Cells. MW :21.2kD. Recombinant Mouse Collagen alpha-1(XVIII) chain is produced by our expression system and the target gene encoding His1591-Lys1774 is expressed Endostatin; an endogenous non-glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP-2 and MMP-9; and cathepsins S; B and L. The N-terminal ~27 aa of Endostatin appear to contain the majority of its activity. This region contains zinc binding sites that are thought to be critical for its anti-endothelial and anti-tumor effects; as well as multiple cleavage sites that; when used; can modify its activity. Mouse Endostatin shares 96% aa sequence identity with rat and 85-87% with human; bovine and equine Endostatin. It is predominantly expressed in liver; kidney; lung; skeletal muscle and testis. Endostatin inhibits endothelial cell growth by inducing cell cycle arrest in G1 phase and initiating apoptosis. It is also thought to down-regulate angiogenesis by blocking VEGF-induced endothelial cell migration. Endostatin may also be involved with down-regulation of angiogenesis after establishment of placental circulation in the pregnant uterus.
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Supplier:
- Abeomics
- Type:
- Assay Kits:Collagen
- Manufacturer's Data Sheet:download_pdf.php
