Recombinant Human Sialate O-Acetylesterase/SIAE (C-6His)
Product Sizes
10 µg
£604.00
32-7750-10UG
50 µg
£897.00
32-7750-50UG
About this Product
- SKU:
- 32-7750
- Extra Details:
- Source: Human Cells. MW :57kD. Recombinant Human Sialate O-Acetylesterase is produced by our Mammalian expression system and the target gene encoding Ile24-Lys523 is expressed with a 6His tag at the C-terminus. Sialate O-Acetylesterase (SIAE) belongs to the family of hydrolases; specifically those acting on carboxylic ester bonds. SIAE is widely expressed with high expression levels in the testis; prostate; and colon. SIAE catalyzes N-acetyl-O-acetylneuraminate and H2O to N-acetylneuraminate and acetate. SIAE removes O-acetyl ester groups from position 9 of the parent sialic acid; N-acetylneuraminic acid. SIAE down-regulates B lymphocyte antigen receptor signaling (involving CD22); and is required for immunological tolerance. Loss of function mutations in SIAE are much more frequently found in humans with autoimmune diseases especially rheumatoid arthritis and type 1 diabetes.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Store at -20[o]C; stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
