Recombinant Human Insulin-Degrading Enzyme/IDE/Insulysin (C-6His)
Product Sizes
10 µg
£604.00
32-7738-10UG
50 µg
£897.00
32-7738-50UG
About this Product
- SKU:
- 32-7738
- Extra Details:
- Source: Human Cells. MW :114.25kD. Recombinant Human Insulin-Degrading Enzyme is produced by our Mammalian expression system and the target gene encoding Met42-Leu1019 is expressed with a 6His tag at the C-terminus. Insulin-Degrading Enzyme (IDE) is a secreted enzyme that belongs to the peptidase M16 family. IDE is a large zinc-binding protease and cleaves multiple short polypeptides that vary considerably in sequence. IDE plays a role in the cellular breakdown of insulin; IAPP; glucagon; bradykinin; kallidin; and other peptides; and thereby plays a role in intercellular peptide signaling. IDE degrades amyloid formed by APP and IAPP. IDE may participate in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. IDE; which migrates at 110 kDa during gel electrophoresis under denaturing conditions; has since been shown to have additional substrates; including the signaling peptides glucagon; TGF a and beta-endorphin.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Store at -20[o]C; stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
