Recombinant Human HVEM/TNFRSF14 (C-Fc)
Product Sizes
10 µg
£477.00
32-7662-10UG
50 µg
£562.00
32-7662-50UG
About this Product
- SKU:
- 32-7662
- Extra Details:
- Source: Human Cells. MW :44.5kD. Recombinant Human Tumor Necrosis Factor Receptor Superfamily Member 14 is produced by our Mammalian expression system and the target gene encoding Leu39-Val202 is expressed with a Fc tag at the C-terminus. Herpesvirus entry mediator (HVEM) is a type I membrane protein in the TNF receptor superfamily; and it can both promote and inhibit T cell activity. HVEM is highly expressed on naïve CD4+ T cells; CD8+ T memory cells; regulatory T cells; dendritic cells; monocytes; and neutrophils. It functions as a receptor for BTLA; CD160; LIGHT/TNFSF14; and Lymphotoxin-alpha. Ligation of HVEM by LIGHT triggers T cell; monocyte; and neutrophil activation and contributes to Th1 inflammation and cardiac allograft rejection. In contrast; HVEM binding to CD160 or BTLA suppresses T cell and dendritic cell activation and dampens intestinal inflammation. HVEM enhances the development of CD8+ T cell memory and Treg function. It is additionally expressed on intestinal epithelial cells; where its binding by intraepithelial lymphocyte (IEL) expressed CD160 promotes epitheilal integrity and host defense. The herpesvirus envelope glycoprotein gD; which binds HVEM to initiate membrane fusion; can antagonize both BTLA and LIGHT binding.
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
