Recombinant Human Serpin A1/alpha-1-Antitrypsin (C-6His)
Product Sizes
10 µg
£562.00
32-7484-10UG
50 µg
£869.00
32-7484-50UG
About this Product
- SKU:
- 32-7484
- Extra Details:
- Source: Human Cells. MW :45.35kD. Recombinant Human Serpin A1 is produced by our Mammalian expression system and the target gene encoding Glu25-Lys418 is expressed with a 6His tag at the C-terminus. Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation; it is synthesized in hepatocytes; and to a lesser extent; in macrophages as well as intestinal epithelial cell lines and secreted as the abundant proteinase inhibitor in the circulation whose targets include elastase; plasmin; thrombin; trypsin; chymotrypsin; and plasminogen activator. Point mutations in the native SerpinA1 variants result in Serpin A1 deficiency; and consequently lead to several clinical complications such as pulmonary emphysema; juvenile hepatitis; cirrhosis; and hepatocellular carcinoma. For example; the Z variants (Glu342 to Lys) forms intracellular inclusion bodies; is not secreted; and leads to a severe SerpinA1 deficiency. Accordingly; Serpin A1 deficiency in circulation is associated with emphysema or liver disease.
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
