Recombinant Human Brain-Specific Angiogenesis Inhibitor 3/BAI3 (C-6His)
Product Sizes
10 µg
£514.00
32-7385-10UG
50 µg
£737.00
32-7385-50UG
About this Product
- SKU:
- 32-7385
- Extra Details:
- Source: Human Cells. MW :97.51kD. Recombinant Human BAI3 is produced by our Mammalian expression system and the target gene encoding Ala25-Thr880 is expressed with a 6His tag at the C-terminus. Human Brain-Specific Angiogenesis Inhibitor 3 (BAI3) is a 177 kDa seven-span transmembrane (TM) protein; which is thought to be a member of the secretin receptor family. It is synthesized by neurons of the CNS and likely is a negative regulator of angiogenesis. BAI3 is 1498 amino acids in size. It contains three distinct regions: an N-terminal extracellular domain (ECD) (aa25-883); a 7-TM segment; and a C-terminal cytoplasmic region. The ECD contains four antiangiogenic TSP type 1 repeat (aa296-508); and one GSP domain (aa 816-867) that is likely used to cleave the ECD from the membrane-bound receptor. There is one altermate splice form that shows a deletion of aa 643-665. Over aa 25-880; human BAI3 shares 98% aa identity with mouse BAI3. BAI3 has been reported primarily in the brain; but is also localized to lung; testis; and pancreas. It might be involved in angiogenesis inhibition and suppression of glioblastoma.
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
