Recombinant Human Platelet-Derived Growth Factor Receptor beta/PDGFR- beta (C-6His)
Product Sizes
10 µg
£456.00
32-7346-10UG
50 µg
£562.00
32-7346-50UG
About this Product
- SKU:
- 32-7346
- Extra Details:
- Source: Human Cells. MW :57.17kD. Recombinant Human PDGF receptor beta is produced by our Mammalian expression system and the target gene encoding Leu33-Phe530 is expressed with a 6His tag at the C-terminus. Platelet-Derived Growth Factor Receptor beta (PDGFR- beta) is a member of the protein kinase superfamily and CSF-1/PDGF receptor subfamily. The PDGF family consists of PDGF-A; -B; -C and -D; which form either homo- or heterodimers (PDGF-AA; -AB; -BB; -CC; -DD). The four PDGFs are inactive in their monomeric forms. The PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-a and - beta. These two receptor isoforms dimerize upon binding the PDGF dimer; leading to three possible receptor combinations; namely -aa; - beta beta and -a beta. The extracellular region of the PDGF receptor- beta consists of five immunoglobulin-like domains while the intracellular part is a tyrosine kinase domain. In addition to being a potent mitogen for cells of mesenchymal origin; PDGF has also been shown to be a potent chemoattractant for mesenchymal cells; mononuclear cells; and neutrophils and has been reported to be important in the modification of cellular matrix constituents.
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
