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Proteins and Peptides

Recombinant Human TRAIL R2/TNFRSF10B/DR5/CD262 (C-6His)

Product Sizes
10 µg
£445.00
32-7300-10UG
50 µg
£530.00
32-7300-50UG
About this Product
SKU:
32-7300
Extra Details:
Source: Human Cells. MW :15.19kD. Recombinant Human TRAIL receptor 2 is produced by our Mammalian expression system and the target gene encoding Ile56-Glu182 is expressed with a 6His tag at the C-terminus. TNFRSF10B is a member of the TNF-receptor superfamily; and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L); and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types; and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region; followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”. TNFRSF10B expression is regulated by the tumor suppressor p53. It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.
Shipping Conditions:
Ambient
Storage Conditions:
Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
Supplier:
Abeomics
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins