Recombinant Human Apoptosis-Inducing Factor 1 Mitochondrial/AIFM1 (N-6His)
Product Sizes
10 µg
£562.00
32-7250-10UG
50 µg
£869.00
32-7250-50UG
About this Product
- SKU:
- 32-7250
- Extra Details:
- Source: E.coli. MW :56.2kD. Recombinant Human Apoptosis-Inducing Factor 1 is produced by our E.coli expression system and the target gene encoding Glu121-Asp613 is expressed with a 6His tag at the N-terminus. Apoptosis-Inducing Factor 1; Mitochondrial (AIFM1) is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. During apoptosis; it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway; while in normal mitochondria; it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces parthanatos i.e.; caspase-independent fragmentation of chromosomal DNA. AIFM1 interacts with EIF3G; and thereby inhibits the EIF3 machinery and protein synthesis; and activates casapse-7 to amplify apoptosis. It binds to DNA in a sequence-independent manner and plays a critical role in caspase-independent; pyknotic cell death in hydrogen peroxide-exposed cells.
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
