Recombinant Human Protein Phosphatase 1 Regulatory Subunit 14A/PPP1R14A (C-6His)
Product Sizes
10 µg
£564.00
32-7140-10UG
50 µg
£787.00
32-7140-50UG
About this Product
- SKU:
- 32-7140
- Extra Details:
- Source: E.coli. MW :17.76kD. Recombinant Human PPP1R14A is produced by our E.coli expression system and the target gene encoding Met1-Pro147 is expressed with a 6His tag at the C-terminus. Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime; PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. PPP1R14A is the inhibitor of PPP1CA. When phosphorylated; PPP1R14A has over 1000-fold higher inhibitory activity; creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. In addition; inhibition of PPP1R14A also enhances contraction of smooth muscle in the absence of increment of intracellular Ca2+ concentration.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Store at -20[o]C; stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
