Recombinant Human Protein Phosphatase 1A/PPM1A (C-6His)
Product Sizes
10 µg
£538.00
32-7139-10UG
50 µg
£686.00
32-7139-50UG
About this Product
- SKU:
- 32-7139
- Extra Details:
- Source: E.coli. MW :43.5kD. Recombinant Human PPM1A is produced by our E.coli expression system and the target gene encoding Gly2-Trp382 is expressed with a 6His tag at the C-terminus. Protein Phosphatase 1A (PPM1A) is a member of the PP2C family of Ser/Thr protein phosphatases which are known to be negative regulators of cell stress response pathways. PPM1A has a broad specificity. PPM1A negatively regulates the activities of MAP kinases and MAP kinase kinases. Also; it negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3; resulting in their dissociation from SMAD4; nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. In addition; PPM1A can dephosphorylate cyclin-dependent kinases; and thus may be involved in cell cycle control.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Store at -20[o]C; stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
