Recombinant Human Heme Oxygenase 1/HO-1
Product Sizes
10 µg
£564.00
32-7127-10UG
50 µg
£787.00
32-7127-50UG
About this Product
- SKU:
- 32-7127
- Extra Details:
- Source: E.coli. MW :29.86kD. Recombinant Human Heme Oxygenase 1 is produced by our E.coli expression system and the target gene encoding Met1-Thr261 is expressed. Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state; the highest activity of HO-1 is found in the spleen; where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals; bromobenzene; endotoxin; oxidizing agents and UVA. HO-1 is involved in the regulation of cardiovascular function and response to a variety of stressors. Defects in HO-1 are the cause of Heme Oxygenase 1 deficiency; resulting in marked erythrocyte fragmentation and intravascular hemolysis; coagulation abnormalities; endothelial damage; and iron deposition in renal and hepatic tissues.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Store at -20[o]C; stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
