Recombinant Mouse Fibroblast Growth Factor 2/FGF-2/FGFb (Met1-Ser154)
Product Sizes
10 µg
£456.00
32-7037-10UG
50 µg
£551.00
32-7037-50UG
About this Product
- SKU:
- 32-7037
- Extra Details:
- Source: E.coli. MW :17.15kD. Recombinant Mouse Fibroblast growth factor 2 is produced by our E.coli expression system and the target gene encoding Met1-Ser154 is expressed. FGF basic is one of 22 mitogenic proteins of the FGF family; which show 35-60% amino acid conservation. Unlike other FGFs; FGF acidic and basic lack signal peptides and are secreted by an alternate pathway. The 17 kDa mouse sequence has 98% aa identity with rat; and 95% identity with human; bovine; and sheep FGF basic. Binding of FGF to heparin or cell surface HSPG is necessary for binding; dimerization and activation of tyrosine kinase FGF receptors. FGF basic binds other proteins; polysaccharides and lipids with lower affinity. Expression of FGF basic is nearly ubiquitous but disruption of the mouse FGF basic gene gives a relatively mild phenotype; suggesting compensation by other FGF family members. FGF basic modulates such normal processes as angiogenesis; wound healing and tissue repair; embryonic development and differentiation; neuronal function and neural degeneration. Transgenic overexpression of FGF basic results in excessive proliferation and angiogenesis is reminiscent of a variety of pathological conditions.
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
