ErbB3 Mouse
Product Sizes
2 µg
£452.00
32-6967-2UG
10 µg
£528.00
32-6967-10UG
About this Product
- SKU:
- 32-6967
- Additional Names:
- Receptor tyrosine-protein kinase erbB-3; Glial growth factor receptor; Proto-oncogene-like protein c-ErbB-3.
- Extra Details:
- Source: Sf9; Baculovirus cells.Sterile Filtered colorless solution.ErbB3; also called Her3 (human epidermal growth factor receptor 3); is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors. Among ErbB family members; ErbB3 is unique in that it contains a defective kinase domain. ErbB3 is expressed in keratinocytes; melanocytes; skeletal muscle cells; embryonic myoblasts and Schwann cells. Monomeric ErbB3 serves as a low affinity receptor for the heregulins (HRG). ErbB3 can induce specific antibody production in vivo; hence to inhibit tumor cell growth. ErbB-3 can be used to treat early; medium and advanced or post-operative breast cancer with over-expression of ErbB2. According to its mechanism of action; ErbB3 is classified as a therapeutic for cancer.ErbB3 produced in Sf9 Baculovirus cells is a single; glycosylated polypeptide chain containing 630 amino acids (20-641.a.) and having a molecular mass of 69.5kDa (Molecular size on SDS-PAGE will appear at approximately 70-100kDa). ErbB3 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
