TDP1 Human; Sf9
Product Sizes
1 µg
£452.00
32-6919-1UG
5 µg
£528.00
32-6919-5UG
About this Product
- SKU:
- 32-6919
- Additional Names:
- Tyrosyl-DNA phosphodiesterase 1; Tyr-DNA phosphodiesterase 1; TDP1; FLJ11090; MGC104252.
- Extra Details:
- Source: Sf9; Baculovirus cells.Sterile Filtered clear solution.TDP1 belongs to the phospholipase D family and contains two PLD phosphodiesterase domains. TDP1 is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. TDP1 may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate; suggesting a role in repair of free-radical mediated DNA double-strand breaks. Mutations in the TDP1 gene are linked to the disease spinocerebellar ataxia with axonal neuropathy (SCAN1).TDP1 Human Recombinant produced in Sf9 Baculovirus cells is a single; glycosylated polypeptide chain containing 617 amino acids (1-608) and having a molecular mass of 69.5kDa. TDP1 is fused to 9 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
