LGMN Human
Product Sizes
2 µg
£452.00
32-6834-2UG
10 µg
£528.00
32-6834-10UG
About this Product
- SKU:
- 32-6834
- Additional Names:
- Legumain; PRSC1; Protease; Cysteine; 1 (Legumain); Asparaginyl Endopeptidase; Protease; Cysteine 1; EC 3.4.22.34; Cysteine Protease 1; LGMN1; AEP.
- Extra Details:
- Source: Sf9; Baculovirus cells.Sterile filtered colorless solution. Legumain; also known as LGMN; is a cysteine endopeptidase which demonstrates strict specificity for hydrolysis of asparaginyl bonds. Furthermore; LGMN can also cleave aspartyl bonds slowly; in particular under acidic conditions. LGMN plays an essential role in the endosomal/lysosomal degradation system as the Legumain deficiency causes the accumulation of pro cathepsins B; H & L; another group of lysosomal cysteine proteases. Furthermore; over expression of LGMN in tumors is important for invasion/metastasis.LGMN produced in Sf9 Baculovirus cells is a single; glycosylated polypeptide chain (18-433 a.a.) and fused to a 6 aa His Tag at C-terminus containing a total of 422 amino acids and having a molecular mass of 48.4kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).LGMN is purified by proprietary chromatographic techniques.
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
