HPSE Active
Product Sizes
1 µg
£452.00
32-6806-1UG
4 µg
£528.00
32-6806-4UG
About this Product
- SKU:
- 32-6806
- Extra Details:
- Heparanase is an endo Beta-D-glucuronidase; which degrades heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix. Heparanase plays an important role in ECM degradation; facilitating the migration and extravasation of tumor cells and inflammatory leukocytes (1;2;3). Upon degradation; heparanase releases growth factors and cytokines that stimulate cell proliferation and chemotaxis (4;5). Heparanase is a heterodimer comprised of a 50 kDa subunit harboring the active site and a 8 kDa subunit. It is produced as a latent 65 kDa precursor and proteolytically processed to its active form (1;6). Heparanase is highly expressed in myeloid leukocytes (i.e. neutrophils) in platelets and in human placenta. Human heparanase was found to be upregulated in various types of primary tumors; correlating in some cases with increased tumor invasiveness and vascularity and with poor prospective survival (7;8).Heparanase Active Enzyme is produced in CHO cells.The protein is purified by several orthogonal chromatography steps.
- Purification:
- Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -80[o]C ; avoid repeated freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
