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Antibodies

ACE2 (18-740) Human; Biotin

Product Sizes
1 µg
£528.00
32-6634-1UG
5 µg
£665.00
32-6634-5UG
About this Product
SKU:
32-6634
Additional Names:
ACE-2 (Angiotensin converting enzyme 2) an enzyme bound to cell membranes in various organs such as intestines arteries ; lungs; heart & kidney. ACE2 an entry receptor of SARS coronaviruses as well as SARS-CoV-2;.The coronavirus spike (S) glycoprotein is a class I viral fusion antigen located on th
Extra Details:
Source: HEK293 CellsSterile Filtered clear solution.ACE-2 (Angiotensin converting enzyme 2) an enzyme bound to cell membranes in various organs such as intestines arteries ; lungs; heart & kidney. ACE2 an entry receptor of SARS coronaviruses as well as SARS-CoV-2;.The coronavirus spike (S) glycoprotein is a class I viral fusion antigen located on the external envelope of the virion that takes part in a critical part in viral infection by identifying host cell receptors and facilitating fusion of the viral and cellular membranes. 2 main domains in coronavirus S1 have been recognized; the N-terminal domain and C-terminal domain. One or the other and/or both S1 domains function as a receptor-binding domain. SARS-CoV + MERS-CoV equally use C-domain to attach their receptors.ACE2 is a type I transmembrane antigen with an extracellular N-terminal domain having the catalytic site and an intracellular C-terminal tail. ACE2 obtains a signal peptide; a transmembrane domain; and a single metalloproteinase active site containing an HEXXH zinc-binding domain. ACE-2 plays a role as a mono-carboxypeptidase which degrades Ang I to produce the nonapeptide Ang 1–9 and Ang II to create the heptapeptide Ang 1–7.The HEK293 derived ACE2 Human recombinant biotinylated protein contains the amino acids Gln 18-Ser 740 fused to His-AVI tag at C-terminal having a predicted Mw of 87.2 kDa ( migrates 95-125 kDa under reducing conditions on sds-page due to glycosilation). ACE2 Protein binds to SARS Coronavirus-2 [ CoV-2019 ] Spike receptor binding domain.
Purification:
ACE-2 Protein is >90% pure as determined SDS-PAGE.
Shipping Conditions:
Blue Ice
Storage Conditions:
ACE-2 Human Recombinant Protein is shipped on ice packs. Upon arrival; Store at -20[o]C. The addition of 0.1% albmin is highly recommended for long term storage use.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody