Lungkine Mouse
Product Sizes
5 µg
£452.00
32-6609-5UG
20 µg
£528.00
32-6609-20UG
About this Product
- SKU:
- 32-6609
- Additional Names:
- C-X-C motif chemokine 15; Lungkine; Small-inducible cytokine B15; Cxcl15; Scyb15.
- Extra Details:
- Source: Escherichia Coli.Sterile Filtered White lyophilized (freeze-dried) powder.Mouse Lungkine/CXCL15 (WECHE) belongs to the ELR motif-containing CXC chemokines. The mouse Lungkine gene has been mapped to chromosome 5. The cDNA of mouse Lungkine encodes a 166 amino acids (aa) protein with a 25 aa predicted signal peptide and a 141 aa mature protein with an exceptionally long C-terminal tail which extends beyond beyond the chemokine fold. Lungkine protein is secreted into bronchoalveolar space and is involved in lung-specific neutrophils trafficking. Furthermore; studies in Lungkine knockout mice propose that Lungkine is an imperative mediator of neutrophil migration from the lung parenchyma into the airspace. In addition; Lungkine is chemotactic for bone marrow progenitor cells and modulates hematopoietic cell differentiation. By Northern blot analysis and in-situ hybridization; Lungkine transcripts have only been specifically detected in the adult and fetal lung; and its expression is up-regulated under inflammatory conditions. There is a 35% aa sequence similarity between the mouse Lungkine and the human ENA-78 and a 31% similarity with the human IL-8.Recombinant Mouse Lungkine produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 142 amino acids and having a molecular mass of 16.4kDa.The CXCL15 is purified by proprietary chromatographic techniques.
- Purification:
- Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Lyophilized Lungkine although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution CXCL15 should be stored at 4[o]C between 2-7 days and for future use below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Biomaterials:Tissues
- Manufacturer's Data Sheet:download_pdf.php
