Recombinant Mouse BCMA
Product Sizes
50µg
£807.00
32-6502-50UG
About this Product
- SKU:
- 32-6502
- Additional Names:
- B-cell maturation protein; Bcm; Bcma; CD269; Tnfrsf17; Tumor necrosis factor receptor superfamily member 17
- Extra Details:
- Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF41-4 and April/TALL-2; respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors; BCMA (for B cell maturation protein); TACI; and BAFF-R; for BAFF were recently identified. BCMA; like TACI; binds BAFF and April. BAFF and its receptors induce B cell development and survival; activate NF-kB and c-jun N-terminal kinase; and are involved in B cell associated autoimmune diseases. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface; BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development; function and regulation. Mouse and human BCMA share 62% amino acid identity.
- Format:
- Purified
- Purification:
- >95% by SDS-PAGE and analyzed by silver stain.
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- This lyophilized protein is stable for six to twelve months when stored desiccated at -20[o]C to -70[o]C. After aseptic reconstitution; this protein may be stored at 2[o]C to 8[o]C for one month or at -20[o]C to -70[o]C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
