Recombinant Human B Cell Maturation Antigen (BCMA)
Product Sizes
50µg
£807.00
32-6501-50UG
About this Product
- SKU:
- 32-6501
- Additional Names:
- B-cell maturation protein; BCM; BCMA; CD269; TNFRSF17
- Extra Details:
- BCMA; also known as TNFRSF17; is a type III membrane protein and member of the TNF receptor superfamily; which are critically involved in the maintenance of homeostasis of the immune system (1). BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface; BCMA appears to be localized to the Golgi compartment (2). Both BAFF and APRIL are ligands for BCMA (4-5). BCMA/BAFF binding induces B cell development and survival; activates NF-kappaB and c-jun N-terminal kinase; and is involved in B cell associated autoimmune diseases. The binding of BCMA to APRIL has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells (4). This data suggests that BCMA may play an important role in B cell development; function and regulation. BCMA also binds B-lymphocyte stimulator (BLyS) (6).
- Purification:
- >95% by SDS-PAGE and analyzed by silver stain.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- This lyophilized protein is stable for six to twelve months when stored desiccated at -20[o]C to -70[o]C. After aseptic reconstitution; this protein may be stored at 2[o]C to 8[o]C for one month or at -20[o]C to -70[o]C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
