IL23R Human
Product Sizes
2 µg
£452.00
32-6470-2UG
10 µg
£528.00
32-6470-10UG
About this Product
- SKU:
- 32-6470
- Additional Names:
- Interleukin 23 Receptor; IL-23 Receptor; IL-23R; IL23R.
- Extra Details:
- Source: Sf9; Baculovirus cells.Sterile filtered colorless solution.Interleukin-23 receptor (IL23R) is a member of the type I cytokine receptor family; Type 2 subfamily. IL23R contains two fibronectin type-III domains and is expressed by monocytes; Th1; Th0; NK and dendritic cells. IL23R protein pairs with the receptor molecule IL12RB1/IL12Rbeta1; and both are necessary for IL23A signaling. IL23R protein associates constitutively with JAK2 (Janus kinase 2); and it also binds to transcription activator STAT3 in a ligand-dependent manner. IL23R binds IL23 and mediates T-cells; NK cells and perhaps certain macrophage/myeloid cells stimulation most likely by way of activation of the Jak-Stat signaling cascade. IL23R might be responsible for autoimmune inflammatory diseases and be vital for tumorigenesis.Interleukin-23 Receptor Human Recombinant produced in Sf9 Baculovirus cells is a single; glycosylated polypeptide chain containing 574 amino acids (24-355a.a.) and having a molecular mass of 65.3kDa (Molecular size on SDS-PAGE will appear at approximately 70-100kDa).IL23R is fused with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
