Recombinant HIV-2 Envelope
Product Sizes
0.5 mg
£1030.00
32-5601-0.5MG
About this Product
- SKU:
- 32-5601
- Extra Details:
- Source : Escherichia Coli. HIV-2 Envelope recombinant- composes all of the reported immunogenic determinants found in gp39. The gene encoding this fusion protein was synthesized using codons optimized for E.coli expression and doesn't represent a linear HIV-2 envelope sequence. HIV-2 is a non-glycosylated; 135 amino acids polypeptide chain; having a molecular mass of 16;127 Dalton; P.I=5.17. HIV-1 and HIV-2 appear to package their RNA differently. HIV-1 binds to any appropriate RNA whereas HIV-2 preferentially binds to mRNA which creates the Gag protein itself. This means that HIV-1 is better able to mutate. HIV-2 is transmitted in the same ways as HIV-1: Through exposure to bodily fluids such as blood; semen; tears and vaginal fluids.Immunodeficiency develops more slowly with HIV-2.HIV-2 is less infectious in the early stages of the virus than with HIV-1.The infectiousness of HIV-2 increases as the virus progresses.Major differences include reduced pathogenicity of HIV-2 relative to HIV-1; enhanced immune control of HIV-2 infection and often some degree of CD4-independence. Despite considerable sequence and phenotypic differences between HIV-1 and 2 envelopes; structurally they are quite similar. Both membrane-anchored proteins eventually form the 6-helix bundles from the N-terminal and C-terminal regions of the ectodomain; which is common to many viral and cellular fusion proteins and which seems to drive fusion. HIV-1 gp41 helical regions can form more stable 6-helix bundles than HIV-2 gp41 helical regions however HIV-2 fusion occurs at a lower threshold temperature (25°C); does not require Ca2+ in the medium; is insensitive to treatment of target cells with cytochalasin B; and is not affected by target membrane glycosphingolipid composition.
- Purification:
- Greater than 95.0% as determined by HPLC analysis and SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- HIV-2 Envelope although stable at 4[o]C for 1 week; should be stored below -18[o]C. Please prevent freeze thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:1.jpg
