Recombinant HIV-2 gp32; Horseradish Peroxidase Labled
Product Sizes
0.5 mg
£1255.00
32-5597-0.5MG
About this Product
- SKU:
- 32-5597
- Extra Details:
- Source : Escherichia Coli. HIV-2 gp32 HRP Labeled recombinant- contains the full-length sequence of HIV-2 envelope immunodominant regions gp32 having a Mw of 32kDa and fused to a beta-galactosidase at N-terminus. HIV-1 and HIV-2 appear to package their RNA differently. HIV-1 binds to any appropriate RNA whereas HIV-2 preferentially binds to mRNA which creates the Gag protein itself. This means that HIV-1 is better able to mutate. HIV-2 is transmitted in the same ways as HIV-1: Through exposure to bodily fluids such as blood; semen; tears and vaginal fluids.Immunodeficiency develops more slowly with HIV-2.HIV-2 is less infectious in the early stages of the virus than with HIV-1.The infectiousness of HIV-2 increases as the virus progresses.Major differences include reduced pathogenicity of HIV-2 relative to HIV-1; enhanced immune control of HIV-2 infection and often some degree of CD4-independence. Despite considerable sequence and phenotypic differences between HIV-1 and 2 envelopes; structurally they are quite similar. Both membrane-anchored proteins eventually form the 6-helix bundles from the N-terminal and C-terminal regions of the ectodomain; which is common to many viral and cellular fusion proteins and which seems to drive fusion. HIV-1 gp41 helical regions can form more stable 6-helix bundles thanHIV-2 gp41 helical regions however HIV-2 fusion occurs at a lower threshold temperature (25°C); does not require Ca2+ in the medium; is insensitive to treatment of target cells with cytochalasin B; and is not affected by target membrane glycosphingolipid composition.
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- HIV-2 gp-32 although stable at room temperature for 3 weeks; should be stored at 4[o]C.
- Supplier:
- Abeomics
- Type:
- Antibodies:Sera
- Manufacturer's Data Sheet:1.jpg
