Recombinant HIV-1 p24 Core
Product Sizes
0.5 mg
£913.00
32-5560-0.5MG
About this Product
- SKU:
- 32-5560
- Extra Details:
- Source : Escherichia Coli. HIV-1 p24 Core is a 24kDa non-glycosylated polypeptide chain; containing the full length sequence of the HIV-1 p24. Human immunodeficiency virus (HIV) is a retrovirusthat can lead to a condition in which the immune systembegins to fail; leading to opportunistic infections. HIV primarily infects vital cells in the humanimmune systemsuch as helper T cells(specifically CD4+ T cells); macrophagesand dendritic cells. HIV infection leads to low levels of CD4+ T cells through three main mechanisms: firstly; direct viral killing of infected cells; secondly; increased rates of apoptosisin infected cells; and thirdly; killing of infected CD4+ T cells by CD8 cytotoxic lymphocytesthat recognize infected cells. When CD4+ T cell numbers decline below a critical level; cell-mediated immunityis lost; and the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus; part of the family of Retroviridae. Lentiviruses have many common morphologies and biological properties. Many species are infected by lentiviruses; which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded; positive-sense; enveloped RNA viruses. Upon entry of the target cell; the viral RNA genomeis converted to double-stranded DNAby a virally encoded reverse transcriptasethat is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integraseso that the genome can be transcribed. Once the virus has infected the cell; two pathways are possible: either the virus becomes latentand the infected cell continues to function; or the virus becomes active and replicates; and a large number of virus particles are liberated that can then infect other cells.
- Purification:
- Greater than 95.0% as determined by HPLC analysis and SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:1.jpg
