Recombinant Hepatitis B Virus e-Antigen
Product Sizes
25 µg
£528.00
32-5503-25UG
About this Product
- SKU:
- 32-5503
- Extra Details:
- Source : Escherichia Coli. Recombinant hepatitis B virus 'e' antigen produced in E.coli; is a 139 a.a. protein. The HBeAg sequence is derived from HBV adw2 and fused to 6xHis Tag at C-terminus. Hepatitis B virus is the main cause for human liver disease; chronic infection frequently causes liver cancer and cirrhosis. The HBV core gene codes 2 distinct protein products; a 21.5-kDa protein being assembled to form nucleocapsid particles designated HBcAg; which wraps the viral DNA as well as the viral polymerase and RNase H; and a precore protein; designated as HBeAg; which is directly to the endoplasmic reticulum; processed at N- and C-terminally and secreted as non-particulate e-anitgen (HBeAg). The pre-core protein contains an extra 29 N-terminal amino acids; serving as a signal peptide to direct the nascent polypeptide into secretory pathway. After the secretion; mature HBeAg is deleted at the residue 149 C-terminally and retains 10 precore residues N-terminally. HBcAg and HBeAg are distinctly recognized by antibodies but highly cross-reactive at the T-cell level.The e antigen is found in the circulation; it is found during the active HBV infection; positive result indicates the risk for contagiousness; and is also used as indicator for the effectiveness of HBV treatment. Positive anti-HBeAg specifies an active stage of acute HBV infection that is in its final stages; the risk for contagiousness is dramatically reduced.
- Purification:
- Protein is >95% pure as determined by 12% PAGE (coomassie staining).
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- HBeAg although stable at 4[o]C for 1 week; should be stored below -18[o]C. Please prevent freeze thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:1.jpg
