Recombinant Human Visinin-Like Protein-1
Product Sizes
50 µg
£528.00
32-5238-50UG
About this Product
- SKU:
- 32-5238
- Additional Names:
- VISL1||VISL-1||VIS1||VIS-1||VILIP||HLP3||Hippocalcin-like protein 3||VSNL1||VILIP-1||VILIP1||HLP-3||HPCAL3||HUVISL1||Visinin-like protein 1.
- Extra Details:
- Source : Escherichia Coli. VSNL1 Human Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 191 amino acids (1-191 a.a.) and having a molecular mass of 22.1kDa.The VSNL1 is purified by proprietary chromatographic techniques. VSNL1 is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. VILIP1 is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Changes in cellular expression of VSNL1 were found in hipppocampi of schizophrenics; since more interneurons showed immunoreactivity. VILIP1 is expressed in pancreatic beta-cells. VILIP1 elevation enhances insulin secretion in cAMP-associated manner. Down-regulation of VILIP-1 decreased cAMP accumulation but increased insulin gene transcription. VILIP-1 interacts with cell membrane and actin-based cytoskeleton. VSNL1 modulates cAMP-accumulation in C6 glioma cells. HLP3 modulates cGMP-accumulation in transfected neural cells and cerebellar granule neurons.
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
