Recombinant Human Tropomyosin-1
Product Sizes
10 µg
£528.00
32-5109-10UG
About this Product
- SKU:
- 32-5109
- Additional Names:
- Tropomyosin alpha-1 chain||Tropomyosin-1||Alpha-tropomyosin||TPM1||C15orf13||TMSA||CMD1Y||HTM-alpha.
- Extra Details:
- Source : Escherichia Coli. TPM1 Human Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 304 amino acids (1-284 a.a.) and having a total molecular mass of 35kDa (Molecular weight on SDS-PAGE will appear higher). TPM1 is fused to a 20 amino acid His Tag at N-terminus and is purified by proprietary chromatographic techniques. TPM1 is a member of the tropomyosin family which consists of a number of extremely conserved; extensively distributed 35-45 kDa actin-binding proteins that are involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin-1 is composed of 2 alpha-helical chains arranged as a coiled-coil. TPM1 is polymerized end to end alongside the two grooves of actin filaments and provides stability to the filaments. TPM1 binds to actin filaments in muscle and non-muscle cells. TPM1 also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In non-muscle cells TPM1 is implicated in stabilizing cytoskeleton actin filaments. Smooth muscle contraction is controlled by interaction with caldesmon. Alternatively spliced transcript variants encoding a range of isoforms have been described in smooth muscle and non-muscle cells. TPM1 Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues; with higher expression levels in the cardiac tissues; whereas Isoform 10 is expressed in adult and fetal cardiac tissues; but not in skeletal muscle.Mutations in the TPM1 gene are linked to type 3 familial hypertrophic cardiomyopathy.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:1.jpg
