Recombinant Human THAP Domain Containing; Apoptosis Associated Protein 1
Product Sizes
20 µg
£528.00
32-5070-20UG
About this Product
- SKU:
- 32-5070
- Additional Names:
- THAP domain-containing protein 1||THAP1||DYT6.
- Extra Details:
- Source : Escherichia Coli. THAP1 Human Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 237 amino acids (1-213 a.a) and having a molecular mass of 27.5kDa.THAP1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. THAP domain-containing protein 1 (THAP1) is a 213 amino acid protein which is restricted to the nucleoplasm and contains one THAPtype zinc finger; a conserved DNA-binding domain. THAP1 is a DNA-binding transcription regulator which regulates endothelial cell proliferation and G1/S cell-cycle progression. In addition; THAP1 has a pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. THAP1 protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies; and serves as a proapoptotic factor which connects PAWR to PML nuclear bodies.
- Purification:
- Greater than 85.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
