Recombinant Human Smad Nuclear Interacting Protein 1
Product Sizes
20 µg
£528.00
32-4891-20UG
About this Product
- SKU:
- 32-4891
- Additional Names:
- Smad nuclear-interacting protein 1||FHA domain-containing protein SNIP1||SNIP1||FLJ12553||dJ423B22.2||RP3-423B22.3.
- Extra Details:
- Source : Escherichia Coli. SNIP1 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 160 amino acids (258-396 a.a.) and having a molecular mass of 18.8kDa. The SNIP1 is purified by proprietary chromatographic techniques. SNIP1 is smad nuclear interacting protein that contains a forkhead-associated (FHA) domain and acts as a nuclear inhibitor of CBP/p300. SNIP1 is an inhibitor of the TGF-beta signal transduction pathway and is significant in suppressing transcriptional activation dependent on the co-activators CBP and p300. Inhibition of NF-kappa B activity is a function of the N-terminal domain of SNIP1 and involves competition of SNIP1 and the NF-kappa B subunit; RelA/p65; for binding to p300; similar to the mechanism of inhibition of Smad signaling by SNIP1.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- SNIP1 should be stored desiccated below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
