Recombinant Human Mothers Against Decapentaplegic Homolog 4
Product Sizes
50 µg
£528.00
32-4867-50UG
About this Product
- SKU:
- 32-4867
- Additional Names:
- JIP||DPC4||MADH4||SMAD-4||DPC-4||MADH-4||Mothers against decapentaplegic homolog 4||Mothers against DPP homolog 4||SMAD 4||hSMAD4||Deletion target in pancreatic carcinoma 4||SMAD4||SMAD family member 4.
- Extra Details:
- Source : Escherichia Coli. SMAD4 Human Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 572 amino acids (1-552) and having a molecular mass of 62.6 kDa. SMAD4 is fused to a 20 amino acid His-Tag at N-Terminus and purified by standard chromatography techniques. SMAD4 is part of the SMAD family of proteins that mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD4 promotes the binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides the function of activation required for SMAD1 or SMAD2 to stimulate transcription acts as a tumor suppressor. SMAD4 is a target molecule for functional inactivation in cervical cancer. SMAD4 is an important biomarker for malignant transformation atakes part in inducing apoptosis by modulating Bcl-2/Bax balance.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:1.jpg
