Recombinant Human SMAD Family Member 2
Product Sizes
10 µg
£528.00
32-4865-10UG
About this Product
- SKU:
- 32-4865
- Additional Names:
- JV18||MADH2||MADR2||JV18-1||hMAD-2||hSMAD2||MGC22139||MGC34440||SMAD2||Mothers against decapentaplegic homolog 2||Mothers against DPP homolog 2||Mad-related protein 2||SMAD 2||SMAD family member 2.
- Extra Details:
- Source : Escherichia Coli. SMAD2 Human Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 487 amino acids (1-467) and having a molecular mass of 54.4 kDa. SMAD2 is fused to 20 amino acid His-Tag at N-Terminus and purified by standard chromatography techniques. SMAD2 is part of the SMAD family of proteins that mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. Phosphorylated SMAD2 is then able to form a complex with SMAD4 or SARA. These complexes accumulate in the cell nucleus; where they are directly participating in the regulation of gene expression. SMAD2 mediates the signal of the TGF-beta; and therefore regulates multiple cellular processes; such as cell proliferation; apoptosis; and differentiation. SMAD2 is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. TGF-beta 1 acts on adjacent stromal cells to turn on SMAD2 signalling that could lead to stromal decidualization. SMAD2 is the downstream signal transducers of TGF-beta-1 in human dental pulp cells.
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:1.jpg
