Recombinant Human SH2 domain containing 1A
Product Sizes
25 µg
£528.00
32-4837-25UG
About this Product
- SKU:
- 32-4837
- Additional Names:
- SH2 domain-containing protein 1A||Duncan disease SH2-protein||Signaling lymphocytic activation molecule-associated protein||SLAM-associated protein||T-cell signal transduction molecule SAP||SH2D1A||DSHP||SAP||LYP||XLP||EBVS||IMD5||XLPD||MTCP1||FLJ186
- Extra Details:
- Source : Escherichia Coli. SH2D1A Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 148 amino acids (1-128 a.a.) and having a molecular mass of 16.3kDa. The SH2D1A is purified by proprietary chromatographic techniques. SH2D1A acts as an inhibitor of the signaling lymphocyte activation molecule (SLAM) self-association. The SH2D1A protein is expressed at a high level in the thymus and the lung; with a lower level of expression in the spleen and the liver. The SH2D1A protein contains an SH2 domain and a short tail. SH2D1A has a key role in the bidirectional stimulation of T and B cells. Defects in the SH2D1A gene cause the X-linked lymphoproliferative disease (XLPD); aka Duncan disease. The XLPD is distinguished by a rare congenital immunodeficiency following an EBV infection (Epstein-Barr virus).
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- SH2D1A should be stored desiccated below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:1.jpg
