Recombinant Human Secreted Frizzled-Related Protein 4
Product Sizes
10 µg
£528.00
32-4828-10UG
About this Product
- SKU:
- 32-4828
- Additional Names:
- Secreted frizzled-related protein 4||sFRP-4||Frizzled protein||human endometrium||FrpHE||SFRP4||FRPHE||FRP-4.
- Extra Details:
- Source : HEK 293. SFRP4 Human Recombinant produced in HEK cells is a single; glycosylated; polypeptide chain (a.a 19-346) containing a total of 341 amino acids; having a molecular mass of 39kDa (calculated); though it migrates at approximately 55kDa on SDS PAGE; the SFRP4 is fused to a 5 a.a N-terminal linker and an 8 a.a Flag tag at N-Terminus.The Human SFRP4 is purified by proprietary chromatographic techniques. Secreted frizzled-related protein 4 (SFRP4) belongs to the SFRP family which contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs serve as soluble modulators of Wnt signaling. SFRP4 may serve as a regulator of adult uterine morphology and function. SFRP4 increases apoptosis during ovulation possibly via modulation of FZ1/FZ4/WNT4 signaling. SFRP4 also has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. SFRP4 is expressed in proliferative endometrium and several types of ovarian; endometrial and Brest tumors. SFRP4 is expressed in mesenchymal cells and in cardiomyocytes. SFRP4 expression in ventricular myocardium correlates with apoptosis related gene expression. SFRP4 is up-regulated in failing myocardium.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store lyophilized protein at -20[o]C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4[o]C for a limited period of time; it does not show any change after two weeks at 4[o]C.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
