Recombinant Human Sin3A-Associated Protein; 18kDa
Product Sizes
20 µg
£528.00
32-4767-20UG
About this Product
- SKU:
- 32-4767
- Additional Names:
- Histone deacetylase complex subunit SAP18||Sin3-associated polypeptide 18 kDa||Sin3-associated polypeptide p18||Cell growth-inhibiting protein 38||2HOR0202||SAP18||GIG38.
- Extra Details:
- Source : Escherichia Coli. SAP18 Human Recombinant fused with 20 amino acid His tag at N-terminus produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 173 amino acids (20- 172 a.a.) and having a molecular mass of 19.7 kDa.The SAP18 is purified by proprietary chromatographic techniques. SAP18 is a component of the histone deacetylase complex which has a significant role in the regulation of eukaryotic gene expression. SAP18 directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression once bound to the promoter. SAP18 plays an important part in gene-specific recruitment of the HDAC complex by a number of transcription factors including Gli; GAGA; and Bicoid. Histone acetylation is significant in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation is catalyzed by multisubunit complexes. SAP18 is a component of the histone deacetylase complex; which includes SIN3; SAP30; HDAC1; HDAC2; RbAp46; RbAp48; and other polypeptides. SAP18 is a component of a splicing-dependent multiprotein EJC (exon junction complex) placed at splice junction on mRNAs.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
