Recombinant Rhesus Macaque S100 Calcium Binding Protein B
Product Sizes
20 µg
£528.00
32-4758-20UG
About this Product
- SKU:
- 32-4758
- Additional Names:
- Protein S100-B||S100 calcium-binding protein B||S-100 protein subunit beta||S-100 protein beta chain||S100B||NEF||S100||S100beta.
- Extra Details:
- Source : Escherichia Coli. S100B Rhesus Macaque Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 91 amino acids and having a molecular mass of 10.7kDa.The S100B Rhesus Macaque is purified by proprietary chromatographic techniques. S100b is a member of the S100 family of proteins which are a family of EF-hand calcium binding proteins that exist mostly as dimers of the 20 currently identified individual S100 monomers. The S100B homodimer is expressed in cells of the central nervous system; glial cells and in certain peripheral cells e.g. Schwann cells; melanocytes; adipocytes and chondrocytes. S100 proteins are localized either in the cytoplasm or the nucleus of a wide range of cells. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. There are at least 13 members in the S100 gene family; which are located as a cluster on chromosome 1q21; however; S100b is located at 21q22.3. The determination of S100B in serum levels may be used to monitor the extent of brain injury and malignant melanoma. S100b proteins may have a role in Neurite extension; proliferation of melanoma cells; stimulation of Ca2+ fluxes; inhibition of PKC-mediated phosphorylation; astrocytosis and axonal proliferation; and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of the S100b gene are implicated in several neurological; neoplastic; and other types of diseases; including Alzheimer's disease; Down's syndrome; epilepsy; amyotrophic lateral sclerosis; melanoma; and type I diabetes.
- Purification:
- Greater than 97.0% as determined by SDS-PAGE and HPLC analyses.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Lyophilized S100B Rhesus Macaque although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution S100B Rhesus Macaque should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
