Recombinant Human RING1 & YY1 Binding Protein
Product Sizes
10 µg
£528.00
32-4728-10UG
About this Product
- SKU:
- 32-4728
- Additional Names:
- RING1 and YY1 binding protein||Death effector domain-associated factor||Apoptin-associating protein 1||YY1 and E4TF1-associated factor 1||ring1 interactor RYBP||DED-associated factor||APAP-1||DEDAF||YEAF1.
- Extra Details:
- Source : E.coli. RYBP Human Recombinant produced in E. coli is a single polypeptide chain containing 252 amino acids (1-228) and having a molecular mass of 27.4 kDa.RYBP is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. RING1- and YY1-binding protein (RYBP) belongs to the polycomb group (PcG). RYBP interacts with MDM2 and decreases MDM2-mediated p53 ubiquitination; which leads to stabilization of p53 and an increase in p53 activity. RYBP causes cell-cycle arrest and is involved in the p53 response to DNA damage. RYBP interacts with RING1; YY1; Caspase 10; E2F3; E2F2; Mdm2; Abl gene and CBX2. RYBP inhibits ubiquitination and subsequent degradation of TP53; and thus has a role in regulating transcription of TP53 target genes. RYBP may also be involved in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. RYBP may bind to DNA; and promote apoptosis.
- Purification:
- Greater than 85% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
