Recombinant Human Replication Protein A2
Product Sizes
10 µg
£528.00
32-4675-10UG
About this Product
- SKU:
- 32-4675
- Additional Names:
- Replication protein A 32 kDa subunit||RP-A p32||Replication factor A protein 2||RF-A protein 2||Replication protein A 34 kDa subunit||RP-A p34||RPA2||REPA2||RPA32||RPA34.
- Extra Details:
- Source : Escherichia Coli. RPA2 Human Recombinant fused with a 23 amino acid His tag at N-terminus produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 293 amino acids (1-270 a.a.) and having a molecular mass of 31.7kDa. The RPA2 is purified by proprietary chromatographic techniques. Replication Protein A2 (RPA2) is a single stranded DNA binding protein. Human RPA2 is a heterotrimeric protein containing subunits of 14; 32 and 70kDa. The RPA2 protein complex is highly conserved in eukaryotes and is crucial in DNA replication; homologous recombination and nucleotide excision repair. RPA2 C-terminus specifically interacts with the DNA repair enzyme UNG2 and repair factors XPA and Rad52; each of which functions in a different repair pathway. Additionally; RPA2 binds specifically to the SH2 domain of Stat3 in vivo; and overexpression of RPA2 corresponds to the augmented growth factor-stimulated tyrosine phosphorylation and transcription activities of Stat3.
- Purification:
- Greater than 85.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- RPA2 should be stored desiccated below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
