Recombinant Mouse Receptor-Associated Protein Of The Synapse
Product Sizes
20 µg
£528.00
32-4605-20UG
About this Product
- SKU:
- 32-4605
- Additional Names:
- Receptor-Associated Protein Of The Synapse||43 KDa Postsynaptic Protein||Acetylcholine Receptor-Associated 43 KDa Protein||RNF205; RING Finger Protein 205||rapsyn||Receptor-Associated Protein Of The Synapse; 43Kd||43 KDa Receptor-Associated Protein O
- Extra Details:
- Source : Escherichia Coli. RAPSN Mouse Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 435 amino acids (1-412aa) and having a molecular mass of 48.8kDa.RAPSN is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. 43 kDa receptor-associated protein of the synapse (RAPSN); is expressed in the postsynaptic membrane of skeletal muscle. RAPSN is essential for the clustering of nicotinic acetylcholine receptors (nAChR). In addition RAPSN self-associates via at least two of its seven tetra-tricopeptide repeats (TPRs). RAPSN interacts with the large intracellular domain of the nAChR a subunit all the way through the hydrophobic surface of the coiled-coil domain. RAPSN modifies trafficking of AChR within the cell. Overexpression inhibits agrin-induced AChR clustering pathway. RAPSN also plays a role in postsynaptic congenital myasthenic syndromes.
- Purification:
- "Greater than 85% as determined by SDS-PAGE."
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
