Recombinant Prelamin-A
Product Sizes
10 µg
£528.00
32-4495-10UG
About this Product
- SKU:
- 32-4495
- Additional Names:
- Prelamin-A/C||LMNA||LMN1||FPL||IDC||LFP||CDDC||EMD2||FPLD||HGPS||LDP1||LMNC||PRO1||CDCD1||CMD1A||FPLD2||LMNL1||CMT2B1||LGMD1B.
- Extra Details:
- Source : Escherichia Coli. Recombinant Prelamin-A is a 74kDa precursor of the nuclear lamin A protein. Prelamin-A is a structural component of the nuclear lamina and it is encoded by lamin A/C gene (LMNA). Due to the presence of a CAAX box sequence at carboxyl terminus; Prelamin-A in vivo goes through a serial of post-translational modifications; resulting in the farnesylation of the cysteine thiol; removal of the AAX tripeptide; carboxyl-methylation of the cysteinyl carboxy group and proteolysis of 18 C-terminal amino acids residues that lead to mature lamin A. Diverse mutations in the lamin A/C gene are associated with different deseases that are collectively called laminophaties; including Emery-Dreifuss muscular dystrophy; familial partial lipodystrophy; limb girdle muscular dystrophy; dilated cardiomyopathy; Charcot-Marie-Tooth disease; and Hutchinson-Gilford progeria syndrome. Recombinant human prelamin A is fused to a 6 Histidine tag at the N-terminus.
- Purification:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:1.jpg
