Recombinant Human Podoplanin
Product Sizes
25 µg
£528.00
32-4423-25UG
About this Product
- SKU:
- 32-4423
- Additional Names:
- Podoplanin||Glycoprotein 36||PA2.26 antigen||T1A||GP36||GP40||Gp38||OTS8||T1A2||HT1A-1||PA2.26||T1-alpha||PDPN.
- Extra Details:
- Source : Escherichia Coli. PDPN Human Recombinant fused to a 20 a.a N-terminal His-Tag produced in E.Coli is a single; non-glycosylated polypeptide chain (99-207 a.a) containing 130 amino acids and having a molecular mass of 13.4kDa. Podoplanin is a small mucin-like type-1 transmembrane protein; typically expressed in various specialized cell types throughout the body. Podoplanin is a type-I integral membrane glycoprotein with diverse distribution in human tissues. PDPN physiological function is related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. PDPN is expressed in lymphatic progenitor cells and afterwards during mouse development in lymphatic endothelial cells. Podoplanin is a specific marker for lymph vessel endothelial cells. Over-expression of podoplanin significantly elevates endothelial cell adhesion; migration; and tube formation. Inhibition of Podoplanin expression decreases cell adhesion in human dermal lymphatic endothelial cells. Podoplanin is used as a specific marker for lymphatic endothelium in histopathology. Podoplanin expression is increased in nearly all human colon; rectum; and small intestine tumors. AGGRUS may serve as a diagnostic marker that distinguishes seminomas; the majority of which over express the protein; from embryonal carcinoma in testicular germ cell tumors.
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:1.jpg
