Recombinant Human Programmed Cell Death 5
Product Sizes
20 µg
£528.00
32-4417-20UG
About this Product
- SKU:
- 32-4417
- Additional Names:
- Programmed cell death protein 5||TF-1 cell apoptosis-related protein 19||Protein TFAR19||PDCD5||TFAR19||MGC9294.
- Extra Details:
- Source : Escherichia Coli. PDCD5 Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 125 amino acids and having a molecular mass of 14 kDa. PDCD5 is expressed in tumor cells during apoptosis independent of the apoptosis-inducing stimuli. Prior to apoptosis induction; PDCD5 is distributed in both the nucleus and cytoplasm. Once apoptosis is induced; the amount of PDCD5 increases and by relocation from the cytoplasm; it accumulates in the nucleus.PDCD5 protein has a stable helical core conformation consisting of a triple-helix bundle and two dissociated terminal regions. PDCD5 is an important novel protein that regulates both apoptotic and non-apoptotic programmed cell death. PDCD5 functions in the process of apoptosis. Exogenous PDCD5 expression increases the chemosensitivity of K562 leukemia cells to low or high doses of idarubicin in vitro; resulting in increased apoptosis. PDCD5 plays an important role in regulation of apoptotic processes in gastric cancer cells and gastric tumors. PDCD5 plays a role in the pathogenesis of rheumatoid arthritis. -27G/-11A SNP is associated with reduced PDCD5 promoter activity and increased susceptibility to chronic myelogenous leukemia. PDCD5 gene may be a target gene under the control of some important apoptosis-related transcriptional factors during the cell apoptosis.
- Purification:
- Greater than 95.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- PDCD5 although stable 4[o]C for 4 weeks; should be stored desiccated below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:1.jpg
