Recombinant Human Programmed Cell Death 4
Product Sizes
10 µg
£528.00
32-4416-10UG
About this Product
- SKU:
- 32-4416
- Additional Names:
- Programmed cell death protein 4||Nuclear antigen H731-like||Neoplastic transformation inhibitor protein||Protein 197/15a||PDCD4||H731||MGC33046||MGC33047.
- Extra Details:
- Source : Escherichia Coli. PDCD4 Human Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 469 amino acids and having a molecular mass of 51 kDa. PDCD4 is restricted to the nucleus in proliferating cells. Expression of PDCD4 is modulated by cytokines in natural killer and T cells. PDCD4 takes part in apoptosis. PDCD4 is a translation inhibitor targeted for degradation during tumor promotion. PDCD4 promotes colonic neoplastic transformation and tumor invasion. PDCD4 is an important target for microrna R-21 in breast cancer cells. Shortage of PDCD4 expression is associated with colorectal cancer. PDCD4 is swiftly phosphorylated by S6K1 kinase protein & afterwords degraded by ubiquitin ligase SCF in response to mitogens. PDCD4 in response to mitogens allows competent protein synthesis & cell growth. PDCD4 is a proapoptotic protein involved in TGF-beta1-induced apoptosis in human HCC cells; and a tumor suppressor in hepatocarcinogenesis. PDCD4 restraines tumor progression in colon carcinoma cells by the novel mechanism of down-regulating MAP4K1 transcription; with consequent inhibition of c-Jun activation and AP-1-dependent transcription. Overexpression of PDCD4 in carcinoid cells results in inhibition of cell proliferation.
- Purification:
- Greater than 90.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:1.jpg
